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Lying down worsens reflux dramatically when gastric emptying is slowed

By slowing down the emptying of food from the stomach, semaglutide makes you feel full for longer, which helps reduce food intake

This observation aligned with previous studies on other tissues, such as the retinal pigment epithelium and the heart, that lipofuscin was found in the lysosomal compartment of the cells 16,35

Sensitivity analyses conducted for all comparisons included: applying only statistically significant differences between the treatment arms

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