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Dosing starts low and is gradually increased over time to improve tolerance and reduce side effects

Available data are insufficient to inform recommendations to mitigate the risk of pulmonary aspiration during general anesthesia or deep sedation in patients taking ZEPBOUND, including whether modifying preoperative fasting recommendations or temporarily discontinuing ZEPBOUND could reduce the incidence of retained gastric contents

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He emphasized increased water intake, recommended more fiber-rich foods, and suggested a safe fiber supplement

Maintenance phase: settle at the lowest dose that delivers the desired effect