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Retatrutide's Glucagon Component: An Additional Layer Unlike semaglutide and tirzepatide, retatrutide activates the glucagon receptor

However, lower rates of weight reduction (5 %) have been reported in real-world studies of patients with obesity with or without comorbid type 2 diabetes [20,21]
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[DOI] [PMC free article] [PubMed] [Google Scholar] Hollenstein K, Kean J, Bortolato A, Cheng RK, Dor AS, Jazayeri A, Cooke RM, Weir M, Marshall FH
