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This study aimed to develop and validate a sensitive liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of tirzepatide in rat plasma and to characterize its pharmacokinetic profile

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A CT scan confirmed the diagnosis of massive splenomegaly, and surgery was urgently needed.Massive splenomegaly, a rare disorder where the spleen grows larger than 20 cm and weighs over 1 kg, leads to low levels of haemoglobin, white blood cells, and platelets