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At the same time, rapid weight loss can stress your liver and kidneys, organs that depend on B vitamins and antioxidants for optimal function

If the dosage is too high, these side effects may become more severe and persistent, leading to discomfort and a decreased quality of life

The second submission was in response to a Complete Response Letter issued by the FDA in December 2019

And both produce gastrointestinal side effects that worsen with rapid titration or inappropriate dosing

For example, this plant compound can mimic and enhance the effects of GLP-1 and has been shown to increase GLP-1 secretion from intestinal cells 14

doi: 10.1136/bmj-2024-080679