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Interestingly, in SURPASS-4, the overall cohort of tirzepatide users and those with 30 mg/g UACR experienced an acute dip in eGFR at 12 weeks, resembling the eGFR slope observed in trials with semaglutide and other nephroprotective drugs, such as RAAS blockers [50] and SGLT-2i [51]

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Provided your hypothyroidism is well-controlled with levothyroxine and you receive appropriate monitoring, GLP-1 medications can be safely prescribed when clinically indicated for type 2 diabetes or weight management

How to Prevent Bruising When Injecting Semaglutide Proper site rotation is the first line of defense

This means using Wegovy after a sleeve falls outside the original STEP trial evidence base

If you're looking for weight loss support that's backed by evidence, speak to a clinician about options that have actually been tested and proven to work