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[DOI] [PubMed] [Google Scholar] 296.Cogswell, J

For symptom management of neuropathic pain, the American Academy of Neurology and American Diabetes Association guidelines recommend: First-line: Duloxetine or pregabalin (with appropriate renal dose adjustments) Alternative options: Gabapentin (with renal dose adjustments) or tricyclic antidepressants (with caution in older adults and cardiac disease) Topical treatments: Capsaicin 8% patch or lidocaine 5% patch for localized symptoms Avoid chronic opioid therapy due to limited evidence and safety concerns Non-pharmacological approaches including physical therapy, proper foot care, and pain psychology techniques provide additional benefit

434,435,480482 The main side effect of finerenone is hyperkalemia, which usually can be managed with dietary restriction and concurrent use of diuretics or SGLT2is (Table 12)

Changes in muscle function and sarcopenia Handgrip strength increased significantly both at M7 (+3.7 kg) and M12 (+4.1 kg) compared to baseline (Figure 2C)