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Clinicians can support individuals by conducting group medical visits or shared medical appointments (see below), recommending in-person or virtual participation in weight management groups or peer-support groups, and addressing barriers to social engagement, such as isolation or mobility challenges [193,194]

Pros: Cons: Best for: Most patients, especially those new to self-injection

Common injection sites include the abdomen, thighs, and upper arms

This causal link is supported by robust molecular evidence from models such as the db/db mouse, in which nuclear localization of ATF4 in -cells correlates with diminished insulinotropic responses and accelerated mass loss (Lee et al., 2023) ( Figure 1 , left)