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Interestingly, GLP-2 administration leads to a reduction in PTH levels in people with an intact intestine, but not in those with short bowel syndrome, 63 indicating that an intact small intestine is required for GLP-2 mediated suppression of PTH secretion

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JAMA Intern Med 182 , 513519 (2022)

Most patients notice a decrease in appetite within the first week, and measurable weight loss within the first month

And during a reset period, it becomes even more critical

Safety and efficacy of IDegLira titrated once weekly versus twice weekly in patients with type 2 diabetes uncontrolled on oral antidiabetic drugs: DUAL VI randomized clinical trial