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Metformin was first approved in Canada in 1972, and received subsequent FDA approval in the United States in 1995

doi: 10.1056/NEJMoa1612917 23 HondaJ.KimuraT.SakaiS.MaruyamaH.TajiriK.MurakoshiN.et al
The primary endpoint was the percentage weight loss at six months (M6) compared to baseline
[DOI] [PMC free article] [PubMed] [Google Scholar] 60.Glucagon like peptide-1 receptor expression in the human thyroid gland

But clinicians are also noting mood changes, flattened affect, and potential links to depression in patients with dopamine-related vulnerabilities

A meta-analysis
