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Additionally, a high percentage of participants achieved a weight reduction of 5% or more (85% with 5 mg, 89% with 10 mg, and 91% with 15 mg of tirzepatide)

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Cagrilintide added to tirzepatide represents a more advanced combination targeting the amylin pathway in addition to GLP-1 and GIP

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The change in glycemia was observed alongside profound reductions in total daily insulin dose in the tirzepatide group (between-group difference 35% of baseline total daily insulin dose [95% CI 47 to 21%]

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With semaglutide, its about 16%

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