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Josephson, A

Insulin in the brain: there and back again

Diabetes 60(12):31033109 Yanagimachi T, Fujita Y, Takeda Y et al (2016) Pancreatic glucose-dependent insulinotropic polypeptide (GIP) (130) expression is upregulated in diabetes and PEGylated GIP(130) can suppress the progression of low-dose-STZ-induced hyperglycaemia in mice

Competing interests The authors declare that there is no conflict of interest

However, GIP immunoreactivity was identified in the adult rat brain using a specific monoclonal antibody against GIP (136), suggesting that while GIP is not expressed in the brain, peripheral GIP can reach the deep brain