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The combination of a GLP-1 medication and heavy alcohol use may theoretically increase pancreatitis risk, though definitive evidence for this interaction is lacking

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The National Institute for Health and Care Excellence (NICE) drafted a guidance recommendation that Wegovy becomes available on the NHS for up to 2 years for those with a body mass index (BMI) of over 35 with at least one weight-related comorbidity, or a BMI between 30-34.9 and meet additional criteria for referral to a specialist NHS weight management service

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GLP-1 acts via both hunger-driven and non-homeostatic pathways to centrally mediate appetite suppression, which is a significant contributor to weight lossan important modulator of hepatic steatosis regression and MASH resolution [27, 40]