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It significantly mitigates liver oxidative stress induced by Salmonella typhimurium by suppressing the upregulation of NRF2 protein and its downstream target, HO-1, while also modulating the mRNA expression of the NQO1 gene [88]

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This triple-agonist approach distinguishes Retatrutide from existing therapies like semaglutide, which only targets the GLP-1 receptor, and tirzepatide, which targets both GLP-1 and GIP receptors

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