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We have previously shown that this capillary block and reduction of perfused blood volume are produced by pericyte-mediated constriction 8

**Managing Common Gastrointestinal (GI) Side Effects:** These are the most frequent issues reported in US trials and real-world use: **Nausea:** * **Eat Smaller, More Frequent Meals:** Avoid large meals that overfill the stomach

GLP1R SNPs are associated with AUD in Caucasian and African American subjects, with an association between rs6923761 and AUD observed in an independent cohort of male subjects

Compare that to tirzepatide results showing 15-25% body weight reduction, or semaglutide before and after results demonstrating 10-15% reductions

Companies will continue to innovate to meet the unique needs of different patient populations

The additional mechanism of action could reignite progress and support continued movement toward health goals