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Activated IRS then stimulates PI3K, which subsequently initiates the phosphorylation and activation of Akt, also known as protein kinase B

doi: 10.1001/jama.2009.1549

The weight loss predominantly causes midface volume loss, which HA fillers are ideally suited to replenish, restoring a more youthful contour (notably, HA was considered the best option for 47% of patients)

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