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Forest plot of GLP-1 receptor agonists versus comparators on the risk of Acute respiratory failure

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The eligibility criteria included any case report or case series that documented instances of AP during the administration of GLP-1 RAs

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GLP-1 receptor agonists like semaglutide and tirzepatide activate hunger-suppressing brain pathways and slow stomach emptying, creating dual mechanisms for sustained weight loss

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Surg Obes Relat Dis 18(9):11091119 McGlone ER, Carey I, Velikovi V, Chana P, Mahawar K, Batterham RL et al (2020) Bariatric surgery for patients with type 2 diabetes mellitus requiring insulin: clinical outcome and cost-effectiveness analyses

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They abolished the myocardial protection properties of GLP-1

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Hence, mice lacking GLP-1R only in the peripheral nervous system (PNS) or central nervous system have normal ip and oral glucose tolerance as compared to controls (Sisley et al., 2014)

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