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Stanford points out that if you are losing a significant amount of weight rapidly without exercising, you may leave yourself vulnerable to fractures

Beyond these formal criteria, factors that suggest tirzepatide may be appropriate include: You've tried diet and exercise consistently without achieving sustainable weight loss You have a weight-related health condition that would improve with reduced body weight You don't have absolute contraindications (medullary thyroid carcinoma history, MEN 2, pregnancy, severe gastroparesis) You're prepared to commit to long-term therapy the SURMOUNT-4 trial demonstrated weight regain after discontinuation A licensed clinician through your primary care provider or one of the telehealth providers above can help you determine whether tirzepatide is appropriate for your specific health profile and goals

This discouraged researchers from pursuing GIP as a therapeutic target

How tirzepatide works at lower doses Understanding what happens inside your body at sub-therapeutic doses helps explain both the potential benefits and limitations of microdosing

Acknowledgements A.C., F.P

Questions to ask your doctor if youre considering a switch: Should I stop semaglutide before starting tirzepatide, or overlap