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doi: 10.1152/ajpgi.00065.2023

By activating these two critical pathways, tirzepatide can help regulate blood sugar and reduce appetite, creating an environment in which your body is more responsive to weight-loss efforts

Many treatments approved for T2DM treatment such as sulphonylureas and thiazolidinediones (TZDs) improve glucose metabolism but have the unwanted side effect of causing weight gain (Thule and Umpierrez, 2014) and (Kahn et al., 2006

These are available in different formulations: most are administered as subcutaneous injections (once weekly or once daily), whilst semaglutide is also available as an oral tablet (Rybelsus)

However, there are several case reports (ie

FDA labeling for these medications does not list cortisol reduction as a mechanism of action or therapeutic effect