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She turned to compounded tirzepatide only after her insurance stopped covering the FDA-approved Zepbound

Supplementary Information Acknowledgements The authors thank Edson Fernandes de Assis for performing the cytokine assays with the multiplex platform and the Fiocruz network of technological platforms and the confocal platform from the Oswaldo Cruz Foundation, Fiocruz, Rio de JaneiroManguinhos Mar campus

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Phentermine levels can accumulate in patients with kidney disease, increasing the risk of adverse effects

Suboptimal dosing : Patients may be on a dose intended for diabetes management (0.5-1.0 mg weekly) rather than the higher dose approved for weight loss (2.4 mg weekly)

The same 4 mg daily sublingual dose will produce different circulating drug concentrations in a 150-pound person versus a 300-pound person due to differences in volume of distribution