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Structured physical activity enhances vascular and metabolic health, increases neurotrophic signaling, strengthens synaptic plasticity, and bolsters mitochondrial resilience, with benefits documented across aging, AD, and PD populations (228230)

The p38 MAPK/ nuclear factor kappa B (NF-B) pathway, a cellular signaling cascade known to be involved in inflammation, and its possible contribution to DPN [74], [75]

GLP-1 medications help with that, of course

B6 specifically supports the conversion of tryptophan to serotonin and the production of dopamine, making it directly relevant to the neurochemical mechanisms discussed earlier

The medication's effect on insulin sensitivity offers an additional benefit: stabilized blood sugar reduces the adrenal stress that triggers or worsens hot flashes