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Constipation occurs in

Phentermine and GLP-1 receptor agonists are distinct medications that work through different biological pathways to support weight loss
Dumping syndrome is the set of symptoms seen when largely undigested food from the stomach moves rapidly into the small bowel, especially post gastric surgery.

There is no argument that the drugs are much more potent and faster acting than your bodies natural GLP-1 hormones

However, owing to their peptide-based composition, GLP-1RAs have traditionally required injectable administration, which undermines patient adherence, convenience, and long-term accessibility
