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Studies have shown that certain bacterial genera such as Bacteroides, Akkermansia, Faecalibacterium, Roseburia, and Bifidobacterium are negatively associated with T2DM, while others like Blautia, Fusobacterium, and Ruminococcus are positively associated with T2DM [156]

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In clinical trials, there were no differences observed in the efficacy of Mounjaro in elderly populations

Each category that is positive for the patient equates to a point

76 However, our functional findings in vivo and ex vivo suggest that HCN channels are not required for the GLP-1-induced increase in heart rate

Future trials could help elucidate other potential benefits of GLP-1 drugs beyond sugar control