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Mechanistically, an in vitro study found that exendin-4 inhibited the secretion of IL-1 and TNF- from mouse colonic smooth muscle cells (CSMCs) via the pathway mediated by cAMP and NF-B, thereby exerting anti-inflammatory effects [218]

One analyst indicated at the beginning of 2024 that such medicines were on track to be the best-selling class of drugs in 2024, with close to US$50 billion in annual sales

When considering a GLP-1 probiotic supplement, the goal should be microbiome and digestive support during GLP-1 therapy, not replacing prescription medication or treating side effects without medical guidance

Effects of combined GIP and GLP-1 infusion on energy intake, appetite and energy expenditure in overweight/obese individuals: a randomised, crossover study

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These findings underscore the enhanced therapeutic potential of dual incretin receptor activation in achieving robust and sustained metabolic improvements