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GLP-1R/GIPR receptor activation in the brain also reduces appetite and promotes satiety, supporting development of liraglutide, semaglutide, and tirzepatide for weight loss

In a 2022 study funded by Novo Nordisk, weight loss followed by exercise or a GLP-1 drug improved sperm count, and there doesnt seem to be much risk

Rapid weight loss can also increase gallstone risk

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It signals the brain to reduce hunger, allowing individuals to feel full longer and eat less

0.5] mmHg) after 24 months in the total cohort or any of the subgroups
