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Pediatric obesity-assessment, treatment, and prevention: an Endocrine Society clinical practice guideline

Research participants who followed the gradual escalation protocol in clinical trials achieved an average of 24% total body weight loss by week 48

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Recent studies indicate that metformin strengthens the protective function of the intestinal mucosal barrier by increasing the abundance of Akkermansia muciniphila and the number of goblet cells, resulting in a thicker mucus layer that reduces inflammation in the intestines (Zhou et al., 2016

Furthermore, metformin has been shown to inhibit the replication of multiple viruses, including Influenza A, and herpesviruses such as Cytomegalovirus and Epstein-Barr virus 50,78 , reinforcing its potential antiviral and neuroprotective benefits