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Remarkably, microglia have a typical neurodegenerative signature for conditions such as Alzheimer's disease (AD), multiple sclerosis (MS), or Parkinson's disease (PD) (Butovsky and Weiner, 2018), reacting to injury through morphological changes by increasing microglial proliferation, migration to the target, phagocytosis, activating the inflammasome, and releasing proinflammatory molecules (Diz-Chaves et al., 2022b)
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The smaller barrel spreads each unit across more line space, which makes tiny doses far easier to measure precisely

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Their food intake can be normalized by the administration of physiological doses of -estradiol but not progesterone (11, 13, 21, 22)

The study also highlighted that adverse effects were reported in approximately 50% of the cohort during follow-up, with gastrointestinal symptoms being the most commonly reported adverse effects, including nausea and vomiting
