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In separate trials, tirzepatide 15 mg produced 20.9% average weight loss compared to semaglutide 2.4 mg at 14.9%

With a foreword by Dr Ellie Cannon

Absorption of most medications is typically not impacted as no intestine is bypassed

Understanding a patients full metabolic risk profile including insulin sensitivity, inflammatory markers, hormonal status, and body composition enables our physicians to develop a genuinely personalised strategy for disease prevention, of which GLP-1 therapy may form an important component

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This raises the minimum risk-adjusted value each programme needs to generate to counteract their cost to develop, meaning portfolios with many lower forecast value assets face disproportionate pressure unless they are clearly differentiated or strategically essential