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Data Availability Data sharing is not applicable to this article as no datasets were generated or analysed during the current study

To investigate the ROS generation, the cells were cultured in serum-free medium containing high glucose (HG, 45 mM Dglucose) , normal glucose (NG, 5 mM Dglucose) and 1 mM H 2 O 2 for 12 h

Ten serious adverse events were reported, among them two occurrences of semaglutide-associated obstipation

Neither injection timing nor meal timing affects semaglutide's pharmacology directly

Obesity-associated melanocortin-4 receptor mutations are associated with changes in the brain response to food cues

Large meals overwhelm a system that is already processing food more slowly