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For the main analysis, changes in weight, BMI, HbA1c, and all-cause healthcare resource utilization (HCRU) after 1 year were compared among adjusted semaglutide OW and comparator SGLT2i cohorts, following inverse probability of treatment weighting (IPTW)

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Genetic Predispositions in GLP-1 Pathways and Individual Response Patterns Variations in GLP1R (rs6923761) and GIPR (rs1800437) genes influence how efficiently your cells respond to GLP-1 signaling