compound glp-1 side effects Compounded GLP-1s: Why doctors worry and the FDA is cracking down Compounded GLP-1 Safety: Supervised Weightloss

We present the following article in accordance with the STROBE reporting checklist (available at Methods Data collection The FAERS is a public case reporting database, which contains medication errors and adverse reactions submitted by healthcare professionals, manufactures, patients, and consumers

The median weight change among GLP-1 users was an 11.5% reduction, compared to a 1.9% reduction for metformin users

The Food and Drug Administration (FDA) approved the medication to treat type 2 diabetes but health care providers also prescribe it off-label (uses other than originally intended) for the treatment of obesity or to help with weight management

[DOI] [PMC free article] [PubMed] [Google Scholar] 52.Ben-Shlomo S, Zvibel I, Shnell M, Shlomai A, Chepurko E, Halpern Z, et al

While the effects of GIP receptor antagonism on these outcomes remain unknow, GIPR knockout mice have been shown to exhibit impaired learning and memory, as well as reduced synaptic plasticity (111)

The second article considers problems, side-effects and reasons to avoid GLP-1 and GIP/GLP-1 RAs, while the third reviews their role in weight management