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The expected glucose-lowering efficacy is an important consideration when changing from one glucose-lowering agent to another or when adding a new agent to existing therapy

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Orforglipron 3 mg dose: 4.7% weight loss Orforglipron 12 mg dose: 6.1% weight loss Orforglipron 36 mg dose: 7.9% weight loss Placebo: 1.6% weight loss When bodyweight was compared between groups, orforglipron demonstrated a greater reduction than placebo and other GLP-1 receptor agonists in similar studies
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