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Under-consumption of food, and even water, is a major concern, and GLP-1 RA users often experience substantial loss of lean body mass, sagging skin due to rapid weight loss, nutrient deficiencies, and chronic dehydration

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GLP-1, or glucagon-like peptide-1, is a hormone that helps signal fullness, slow digestion, and support balanced blood sugar levels

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Nonetheless, the magnitude of weight loss observed particularly at the 8 mg and 12 mg doses was described by the investigators as among the most substantial reported in a pharmacological obesity trial to date

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To view a copy of this licence, visit About this article Cite this article Fadini, G.P

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