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SGLT2 inhibitors might not cause EDKA by themselves but instead create a predisposition that can lead to the condition when certain triggering factors are present

Neovius M, Bruze G, Jacobson P, Sjholm K, Johansson K, Granath F, et al

Regulation of age-associated insulin resistance by MT1-MMP-mediated cleavage of insulin receptor

Phase 3 trials: Large scale clinical trials with data used to inform regulatory applications FDA approval: All new drugs in the US need the green light from the US Food and Drug Administration

doi: 10.1038/s41598-018-37215-0 [DOI] [PMC free article] [PubMed] [Google Scholar] 92.Saravia FE, Beauquis J, Revsin Y, Homo-Delarche F, de Kloet ER, De Nicola AF