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Many patients report being denied initially but approved on the first appeal, suggesting that the initial denial is sometimes a screening mechanism rather than a final decision

Tirzepatide was approved in 2022 as Mounjaro for diabetes, and in 2024 as Zepbound for obesity, with exclusivity running until May 2027

For detailed information on current and future availability worldwide, see our retatrutide availability by country guide

What are the most common side effects of Zepbound

83 , 84 Nonetheless, product labeling for GLP-1 RAs advises monitoring volume status, especially in patients with fluid loss or concurrent antihypertensive use

This latest research suggests it can also be a valuable preventative treatment for people at high risk of heart conditions.