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Cardiovascular disorders occurred in 5% to 12% of semaglutide patients versus 10% to 12% of placebo patients, adjudicated cardiovascular events occurred in 0.2% to 2% of semaglutide patients versus 0 to 1% of placebo patients, and hypoglycemia occurred in 0.5% to 0.6% of semaglutide patients versus 0 to 1% of placebo patients in the STEP 1, STEP 3, and STEP 4 studies, respectively

Patients with personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2 should not use GLP-1 receptor agonists due to thyroid C-cell tumor risk observed in animal studies

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Effective communication between you, your surgical team, and your diabetes care providers is essential for safe perioperative management

A study at Penn Medicine, funded by Novo Nordisk, found that participants taking semaglutide lost an average of 16% of their starting weight and more than one-third lost 20% or more of their baseline weight during the 68-week study

This contrasts with the compensatory increase in appetite typically observed with other dietary approaches [134]