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DPP4 is involved in the degradation of GLP-1, GIP, as well as glucagon to biologically inactive fragments

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Zepbound activates GLP-1 and GIP receptors simultaneously-reducing appetite significantly within days, slowing gastric emptying by approximately 40%, and producing average weight loss of up to 21% by week 72

Obstructive sleep apnoea (OSA) is a common and increasingly prevalent disorder characterised by repetitive episodes of upper airway obstruction during sleep, leading to intermittent hypoxia, fragmented sleep and a cascade of physiological disturbances

Safety and cardiovascular monitoring requirements

And for understandable reasons, the drug industry isnt keen to fund studies that show disappointing results