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Once you stop taking the medication, your body's natural appetite signalscontrolled by ghrelin and neuropeptide Yresume their original strength

This is precisely why the titration schedule exists

While GLP-1 microdosing is ideal for maintenance, longevity, and overall wellness support, those with a significant weight-loss goal may be better suited for a standard GLP-1 dose

J Am Coll Surg 213:461-468

Choosing between GLP-1 and GLP-2 (GLP-3 is not a current option) depends entirely on your health goals and conditions: Choose GLP-1 If Youre Focused On: Blood sugar control and diabetes management Weight loss and appetite suppression Metabolic health optimization Cardiovascular risk reduction Overall metabolic syndrome improvement Choose GLP-2 If Youre Dealing With: Short bowel syndrome Inflammatory bowel disease Malabsorption issues Intestinal damage or injury Chronic gut inflammation Need for improved nutrient absorption Consider Medical Consultation Neither GLP-1 nor GLP-2 should be started without proper medical evaluation