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doi: 10.1038/nm.3009 44 CoskunTSloopKWLoghinCAlsina-FernandezJUrvaSBokvistKBet al

3.9 SGLT2 inhibitors Sodium-glucose cotransporter-2 (SGLT2) inhibitors are a group of sodium-depended glucose transporters which are primarily expressed in the proximal tube epithelium of the kidney and are responsible for the majority (over 90%) of filter glucose reabsorption

This is especially true with the new class of drugs being used for weight loss

Verdict at a Glance Pemvidutide and survodutide are both GLP-1/glucagon dual agonists being developed for obesity and MASH, but survodutide is further ahead in clinical development with more advanced Phase 3 programs, higher-tier regulatory designations (Breakthrough Therapy vs Fast Track), and greater weight loss in Phase 2 (18.7% vs 15.6%)