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Wegovy and Zepbound are both considered effective at treating obesity, and were approved by the US Food and Drug Administration to do so

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Tirzepatide overcame this issue, being effective in subjects with obesity independently of the length of the history of obesity, and this was surprising. Muscogiuri said more studies are needed to see whether the similarities in weight loss for adults with different obesity durations are maintained over a long-term period.

Accessed July 11, 2025.

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Semaglutide data vary by cohort and method, but several analyses report substantial lean mass reductions during weight loss phases