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Reassuring clinical data are starting to accrue: two multinational population-based cohort studies found no increased risk of major congenital malformations, live births, pregnancy losses, and pregnancy terminations during the periconceptional period with GLP-1 RAs [139]

What Would Be the Effect of This Decision

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The risk classification in the latter subgroup comparison differs from the prespecified group of evidence of CVD in SUSTAIN 6, in which subjects with CKD stage 3 or higher were included [12]

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Understanding this distinction is essential to avoid conflating device-enabled delivery with classical oral pharmacology