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These effects are often mild to moderate, but they can still disrupt hydration, eating patterns, and adherence

Includes ongoing monitoring, dose adjustment based on response, and a plan for what happens after the medication period ends

More recently, head-to-head data from the SURMOUNT-5 trial, published in The New England Journal of Medicine, showed that tirzepatide produced a mean weight reduction of 20.2 percent compared to 13.7 percent with semaglutide over 72 weeks a difference that researchers described as both statistically significant and clinically meaningful

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Zepbound vs Wegovy vs Ozempic vs Mounjaro: Which GLP-1 Causes the Most Diarrhea

The outcome is decreased circulating FFAs following surplus caloric intake, limiting lipid spillover into ectopic regions and improvement in systemic insulin sensitivity [45]