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R.DenekeE.WassermanE

However, given that large peptides like GLP-1 interact with both the extracellular and transmembrane domains of the GLP-1R ( 32 ), and that our small molecules were unlikely to recapitulate this complex binding mode, it was unclear whether the competition binding experiments with radiolabeled GLP-1 were providing an accurate measure of affinity ( 25 )

New England Journal of Medicine , 389 (24), 22212232

GLP-1s may boost fertility for women with PCOS Polycystic ovarian syndrome (PCOS), an endocrine condition in which a womans ovaries and/or adrenal glands overproduce male sex hormones called androgens, affects 8% to 18% of reproductive-aged women and is a leading cause of infertility in women

P2P review overturns denials about 35-45% of the time when the prescriber comes prepared with chart data and trial evidence