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doi:10.1016/j.diabres.2016.10.024 147

Semaglutide improved cognitive regression in this model of tauopathy through microglial T-polarization mediated by autophagy/ACE2/SIRT1/FOXO1 signaling pathways

The real key is going to be side effects over time, if retatrutide is like other drugs in the class then the side effects should decrease with time, but unfortunately, we dont have that today, at this point I have some questions and minor concerns but without the data over time its hard to speculate about tolerability further beyond saying its similar to other drugs in the class

Common Side Effects (5%): Nausea 15.8% Diarrhea 8.5% Vomiting 5.0% Constipation 5.0% Abdominal pain Less Common Side Effects: Fatigue , dizziness , dysgeusia , increased heart rate Cholelithiasis 1.5% Hypoglycemia (especially with sulfonylurea or insulin) Serious Risks: Pancreatitis Diabetic retinopathy worsening Acute kidney injury Gallbladder disease Hypersensitivity reactions (e.g., anaphylaxis) Proper storage of OZEMPIC 0.5mg (Japanese) is critical to maintain its stability and effectiveness

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On the other hand, GLP-1RAs can also cause gastrointestinal side effects and injection site reactions, while carrying a higher price tag than other therapeutic options like metformin