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Adolescent rats were treated with increasing daily doses of THC for 21 days (1 and 3 and 10 mg/kg)

[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Yu J, et al

GLP-1 Receptor Agonist Market Opportunities: Expanded cardiovascular indications and biosimilar development creating transformative GLP-1 receptor agonist market opportunities The cardiovascular indication expansion following SELECT trial approval for semaglutide in cardiovascular risk reduction in obese non-diabetic patients is qualitatively important because it changes who prescribes GLP-1 drugs

Retatrutide targets three receptors (GIP, GLP-1, and glucagon) compared to two for tirzepatide (GIP and GLP-1) and one for semaglutide (GLP-1)

Our review is supportive of the current recommendation against the use of either of these medications during pregnancy or lactation as either metformin or a variety of insulin analogs are safe during pregnancy (56, 57) and lactation (58, 59)
