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GLP-1 acts through type IIB PKA to mediate its effects on KATP channel activity, Ca channel function and insulin granule morphology, key mechanisms identified by Rui Liu et al GLP-1 boosts insulin release through PKA How does GLP-1 boost insulin release

Others argue the safety is compromised

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Examples of these instruments include the Patient Assessment of Gastrointestinal Disorders Symptoms questionnaire, Gastroparesis Cardinal Symptom Index and Diabetes Bowel Symptom Questionnaire

Ultimately, the goal is not rapid or extreme weight loss but, rather, safe, sustainable, and medically meaningful improvements in health and quality of life