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GLP-1s arent FDA-approved for treating high blood pressure

The main reason for this difference lies in the disparity between preclinical research and clinical research, that is, the contradiction that GLP-1 receptor agonists show muscle-protective effects in animal models but are accompanied by fat-free body weight loss in humans

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This is the actual biological process where continuous stimulation of the GLP-1 receptor causes it to become less responsive

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Reduced gastric inhibitory polypeptide but normal glucagonlike peptide 1 response to oral glucose in postmenopausal women with impaired glucose tolerance