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doi: 10.1001/jama.281.8.727

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In this context, microbiota-targeted interventions such as fecal microbiota transplantation have been proposed as complementary strategies to restore microbial diversity and improve metabolic outcomes, highlighting the broader relevance of hostmicrobiome interactions in shaping antidiabetic drug efficacy ( Baseline microbial profiling may eventually contribute to understanding variability in GLP-1 RA response, but its routine use for therapeutic stratification is not supported by current evidence