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Nature 528 , 262266 (2015)

In preclinical models, GIP has been shown to decrease food intake and increase energy expenditure therefore resulting in weight reductions, and when combined with GLP-1 receptor agonism, may result in greater effects on markers of metabolic dysregulation such as body weight, glucose and lipids. Incretin hormones are released whenever food is consumed

GIP receptor activation further supports energy balance by enhancing nutrient utilization and improving metabolic efficiency

Kamrul-Hasan ABM, Hannan MA, Asaduzzaman M, Rahman MM, Alam MS, Amin MN, et al

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