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Furthermore, we discuss existing data on the molecular composition and functional impact of two predicted GLP-1R nanodomains, one at ERplasma membrane contact sites, where GLP-1R might interact with ion channels and transporters to influence local excitability and coordinated insulin secretion, and another at ERmitochondria membrane contact sites, with the capacity to control lipid and calcium signaling and modulate ER and/or mitochondrial activity

2023;72(Supplement_1) doi: 10.2337/db23-128-OR

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The downside for pharma investors is the cutthroat competition just ask Novo Nordisk about Eli Lillys tirzepatide

Linagliptin, CARMELINA and CAROLINA, Br

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